CRNT4SBML Documentation Status

CRNT4SBML is an easily installable Python based package available on MacOS and Windows. CRNT4SBML is concentrated on providing a simple workflow for the testing of core CRNT methods directed at detecting bistability in cell signaling pathways endowed with mass action kinetics.


  • Routine for testing of the Deficiency Zero and One Theorems.
  • Routine for running the mass conservation approach.
  • Routine for running the semi-diffusive approach.


If you use CRNT4SBML in your research, we would appreciate it if you use the following citation in any works you publish:

Brandon C Reyes, Irene Otero-Muras, Michael T Shuen, Alexandre M Tartakovsky, Vladislav A Petyuk, CRNT4SBML: a Python package for the detection of bistability in biochemical reaction networks, Bioinformatics.


This package was created with Cookiecutter and the audreyr/cookiecutter-pypackage project template.