Steps for Detecting BistabilityΒΆ
The following are some simple steps to follow for detecting bistability using CRNT4SBML:
- Construct an SBML file following the guidelines provided in CellDesigner Walkthrough.
- Check if the conditions for the Deficiency Zero or One Theorems are satisfied using the approach outlined in Low Deficiency Approach.
- If the Deficiency Zero or One Theorems are not satisfied, then use
crnt4sbml.Cgraph.get_dim_equilibrium_manifold()
to find , the number of mass conservation relationships. - If is greater than zero one can use the details described in Mass Conservation Approach Walkthrough to conduct further analysis of a uniterminal network.
- If is greater than zero one can use the details described in General Approach Walkthrough to conduct further analysis of any network.
- If is zero and there is a boundary species present in the SBML file then one can use the details described in Semi-diffusive Approach Walkthrough to conduct further analysis of the network.